English
  • isibhengezo_sekhasi
Isithombe Esifakiwe esingu-6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
  • 6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
  • 6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

Incazelo emfushane:

Igama lamakhemikhali: 6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one

I-CAS: 1256578-99-0

Ifomula yamakhemikhali: C13H15UBrO2

Isisindo sama-molecule: 283.16

Ubuningi：1.3±0.1g/cm3

Indawo yokubilisa：354.7±42.0 ℃（760 mmHg）

 


Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Incazelo Yomkhiqizo

Izinhlobo zamakhemikhali

6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one luwuketshezi olukhanyayo olungenambala kuya koluphuzi olukhanyayo, olungancibiliki emanzini, oluncibilikayo ku-CHCl3, indawo yokugcina kufanele iqandiswe, ihlukaniswe nama-oxidants, amakhemikhali adliwayo, kude nomlilo, nomthombo wokushisa.

Izicelo

6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-oneiyisithako esiphakathi kwe-Alectinib, i-anaplastic lymphoma kinase (ALK) inhibitor ekhetha kakhulu futhi enamandla ekwazi ukuvimba i-gatekeeper mutant engamelani nayo, okuholela ekukhuleni kwamaseli okuncishisiwe.

Ifomu elibonakalayo

Uketshezi olungenambala kuya koluphuzi

Isikhathi sokuphelelwa yisikhathi

Ngokusho kokuhlangenwe nakho kwethu, umkhiqizo ungagcinwa izinsuku ezingu-12.izinyanga kusukela osukwini lokulethwa uma zigcinwe ezitsheni ezivalwe kahle, zivikelwe ekukhanyeni nasekushiseni futhi zigcinwe emazingeni okushisa aphakathi kuka-5 -30°C.

Tizakhiwo ezivamile

Indawo Yokubilisa

354.7±42.0 °C ku-760 mmHg

Iphoyinti Elikhanyayo

168.3±27.9 °C

Isisindo Esiqondile

282.025543

I-PSA

26.30000

I-LogP

3.25

Ukucindezela Komusi

0.0±0.8 mmHg ku-25°C

Inkomba Yokuqabula

1.545

i-pka

1.26±0.10 (Kubikezelwe)

Ukuncibilika Kwamanzi

50 mg/ml ku-CHCl3

 

 

Ukuphepha

Uma uphatha lo mkhiqizo, sicela ulandele iseluleko nolwazi olunikezwe ephepheni ledatha yokuphepha futhi ulandele izinyathelo zokuvikela nezokuhlanzeka endaweni yokusebenza ezifanele zokuphatha amakhemikhali.

 

Inothi

Idatha equkethwe kulolu shicilelo isekelwe olwazini lwethu lwamanje kanye nokuhlangenwe nakho. Ngenxa yezici eziningi ezingase zithinte ukucutshungulwa nokusetshenziswa komkhiqizo wethu, le datha ayibakhululi abaprosesa ekwenzeni uphenyo lwabo kanye nokuhlolwa; futhi le datha ayisho noma yisiphi isiqinisekiso sezakhiwo ezithile, noma ukufaneleka komkhiqizo ngenhloso ethile. Noma yiziphi izincazelo, imidwebo, izithombe, idatha, izilinganiso, izinsimbi, njll. ezinikezwe lapha zingashintsha ngaphandle kolwazi lwangaphambilini futhi azihlanganisi ikhwalithi yesivumelwano esivunyelwene ngayo yomkhiqizo. Ikhwalithi yesivumelwano esivunyelwene ngayo yomkhiqizo iphumela kuphela ezitatimendeni ezenziwe ekucacisweni komkhiqizo. Kungumthwalo wemfanelo womamukeli womkhiqizo wethu ukuqinisekisa ukuthi noma yimaphi amalungelo obunikazi kanye nemithetho ekhona kanye nemithetho kuyagcinwa.

  • Okwedlule:
  • Olandelayo:

    • OkuhlobeneIMIKHIQIZO